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April 21, 2026Annals of the Rheumatic Diseases2 citationsOpen Access

Human hypofunctional NCF1 variant aggravates salivary gland immunopathology in Sjögren’s disease by promoting switched memory B-cell recruitment and long-lived plasma cell differentiation

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XYXinran YuanXQXiaodong QinXWXinjie Wu

Key Points

  • The aim is to understand how low NCF1 activity influences immunological responses in Sjögren’s disease.
  • Analyzed the effects of NCF1 variants on switched memory B-cell recruitment
  • Investigated IgG+ plasma cell differentiation in the context of Sjögren’s disease
  • Low NCF1 activity significantly increases switched memory B-cell trafficking.
  • Increased differentiation of IgG+ plasma cells is associated with NCF1 hypofunction.

Abstract

Low NCF1 activity increases the risk of severe SSA+ SjD by driving switched memory B-cell trafficking and IgG+ plasma cell differentiation, revealing targetable pathways in SSA+ SjD.

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69e7138bcb99343efc98d011https://doi.org/10.1016/j.ard.2026.03.026
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