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April 22, 2026International Endodontic Journal0 citations

The Role of SERPINE1 in Coordinating Osteogenesis and Angiogenesis of hDPSCs for Bone Regeneration

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BLBang LiRGRonghua GuanCZChaoning Zhan

Key Points

  • This research aims to explore the role of SERPINE1 in bone regeneration by regulating osteogenesis and angiogenesis in human dental pulp stem cells (hDPSCs).
  • Utilized a HA/CS MS delivery system to study the functions of SERPINE1.
  • Investigated the interaction between osteogenesis and angiogenesis in hDPSCs.
  • Established SERPINE1 as a key regulator in facilitating both bone and blood vessel formation.
  • Demonstrated the efficacy of the delivery system in promoting robust vascularised bone formation.

Abstract

This study establishes SERPINE1 as a crucial hub regulator that coordinates osteogenesis and angiogenesis in hDPSCs. The utilisation of the HA/CS MS delivery system effectively harnesses this dual-functionality, promoting robust vascularised bone formation. These findings provide a novel theoretical basis and a promising translational strategy for biomaterial-based bone tissue engineering.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69e865476e0dea528dde9dc3https://doi.org/10.1111/iej.70166
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