Higher LDL-C/HDL-C ratio, coagulation indicators, and blood routine parameters positively correlated with coronary lesion severity and independently predicted MACE within 100 days (p<0.05).
Observational (n=159)
In early-onset coronary heart disease, the LDL-C/HDL-C ratio, coagulation indicators, and blood routine parameters correlate with anatomical severity and independently predict short-term MACE.
p-value: p=<0.05
Background: This study aims to investigate the correlation between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, in combination with complete blood count and coagulation panel parameters, and both the severity of coronary artery lesions and prognosis in patients with early-onset coronary heart disease, and to provide novel, comprehensive clinical indicators for risk assessment and prognosis evaluation in this patient population. Methods: A retrospective study was conducted on the clinical data of 159 patients diagnosed with early-onset coronary heart disease through initial coronary angiography between January 2023 and August 2025. Patients were categorized into three groups based on coronary lesion severity: a mild lesion group (n = 78), a moderate disease group (n = 59), and a severe disease group (n = 22). Lipid profiles total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C, LDL-C/HDL-C ratio, fasting blood glucose, uric acid, and coagulation parameters prothrombin time (PT), prothrombin time ratio (PTR), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), complete blood count hemoglobin (HGB), red cell distribution width-coefficient of variation (RDW-CV), red cell distribution width-standard deviation (RDW-SD), mean platelet volume (MPV), platelet distribution width (PDW) were detected, and the correlation between statistically significant indicators and the severity of coronary artery lesions was analyzed. Participants were divided into the MACE group and the non-MACE group based on the occurrence of major adverse cardiac events (MACE) within 100 days, and binary logistic regression analysis was applied to identify MACE risk factors. Results: The severe group showed higher TC, LDL-C, LDL-C/HDL-C, fasting blood glucose, and uric acid levels than the moderate group, which in turn had higher levels than the mild group; TG was higher than in the moderate/mild groups; HDL-C was lower than in the moderate group but higher than in the mild group (p p p > 0.05); however, the severe group had higher RDW-CV, RDW-SD, MPV, and PDW than the moderate group, and the mild group had the lowest (p τ = 0.375, 0.372, 0.346, 0.448, 0.305, 0.239, 0.388, 0.310, 0.299, 0.447, 0.364, 0.476, 0.226, 0.401, 0.466, p τ = –0.410, p χ2 = 23.283, p p < 0.05). Conclusion: In patients with early-onset coronary heart disease, LDL-C/HDL-C ratio, coagulation function indicators (PT, APTT, TT, FIB), and blood routine parameters (RDW-SD, PDW) show significant positive correlations with the anatomical severity of coronary artery lesions and are closely associated with increased short-term adverse prognosis risk.
Zhang et al. (2026) conducted an observational in Early-onset coronary heart disease (n=159). LDL-C/HDL-C ratio, complete blood count, and coagulation parameters was evaluated on Major adverse cardiac events (MACE) within 100 days (p=<0.05). Higher LDL-C/HDL-C ratio, coagulation indicators, and blood routine parameters positively correlated with coronary lesion severity and independently predicted MACE within 100 days (p<0.05).