Although the exact pathophysiology of APMPPE remains uncertain, increasing evidence suggests an immune-mediated vasculitic mechanism rather than primary ischemia alone. This case is noteworthy as APMPPE revealed previously undiagnosed Crohn's disease. It highlights the need for systemic evaluation in atypical presentations, especially when granulomatous anterior involvement is present. Modern multimodal imaging, including OCT, provided precise characterization of the lesions and contributed to the comprehensive evaluation of this rare association.
Fricker et al. (2026) studied this question.