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April 23, 2026Discover Oncology0 citationsOpen Access

Clinical presentation and treatment of plasmablastic myeloma-a multicenter retrospective analysis

ZLZhenhui LvXGXiaoqing GuoJYJunjing Yin

Key Points

  • This research aims to characterize the clinical features and explore treatment options for plasmablastic myeloma.
  • Multicenter retrospective analysis of patient data
  • Assessment of clinical presentation and treatment responses
  • Exploration of potential therapies like CAR-T and allogeneic stem cell transplantation
  • Plasmablastic myeloma shows rapid progression and high tumor burden
  • Observed poor prognosis with prevalent high-risk genetic abnormalities
  • Potential new treatment avenues include CAR-T therapy and allogeneic transplantation.

Abstract

PBM has a low incidence, rapid cell proliferation, high tumor burden, multiple high-risk genetic abnormalities, rapid progression and poor prognosis. PBM frequently affects extramedullary sites. There is currently no standard treatment for PBM. CAR-T therapy may be a new option. Allogeneic hematopoietic stem cell transplantation is also the direction of exploration.

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Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/69e9b62685696592c86eae41https://doi.org/10.1007/s12672-026-05071-4
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