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April 23, 2026Neurosurgery2 citations

Pre-existing Gut Microbiome Dysbiosis Exacerbates Neuroinflammation and Vasospasm After Subarachnoid Hemorrhage in Mice

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HMHidetoshi MatsukawaMFMitsugu FujitaKindai University HospitalYKYoji KuramotoHyogo Medical University

Key Points

  • The study aims to explore how pre-existing gut microbiome dysbiosis affects neuroinflammation and vasospasm post-subarachnoid hemorrhage (SAH).
  • Utilized a mouse model to simulate subarachnoid hemorrhage (SAH).
  • Examined the impact of pre-existing gut microbiome dysbiosis on immune responses and neurological outcomes.
  • Assessed neurovascular inflammation and vasospasm severity post-SAH.
  • Pre-existing gut microbiome dysbiosis significantly exacerbated neuroinflammation and vasospasm after SAH.
  • Dysregulated immune responses were observed, linking gut health to brain pathology.
  • Demonstrated that targeting the gut microbiome could provide new therapeutic options for managing SAH.

Abstract

Pre-existing GMD exacerbates neurovascular inflammation, vasospasm, and neurological impairment after SAH through dysregulated central and systemic immune responses. These findings identify the gut-brain axis as a critical modulator of delayed cerebral ischemia-like pathology and suggest microbiome-targeted strategies as potential therapeutic approaches for SAH.

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Cite This Study

Matsukawa et al. (2026) studied this question.

synapsesocial.com/papers/69e9b80e85696592c86eb875https://doi.org/10.1227/neu.0000000000004035
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