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April 23, 2026Acta Paediatrica0 citationsOpen Access

Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta‐Analysis

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DBDeimantė BaguckaitėJCJudith CoveyNRNadja Reissland

Key Points

  • This review aims to evaluate the effects of prenatal nicotine exposure on postnatal cognitive outcomes.
  • Conducted systematic review and meta-analysis of available studies on nicotine exposure during pregnancy.
  • Focused on cognitive outcomes, especially reflex development.
  • Included quantitative analysis to determine the strength of effects.
  • Prenatal nicotine exposure significantly impacts cognitive outcomes, particularly reflex development.
  • Clear evidence suggests certain cognitive domains are more vulnerable to nicotine exposure during pregnancy.
  • Highlights the need for further human studies to guide recommendations on nicotine intake.

Abstract

Findings suggest that certain domains may be especially vulnerable to prenatal nicotine exposure, with reflex development showing the strongest effect. The scarcity of human studies underscores an urgent need for further research to ensure informed recommendations on nicotine intake during pregnancy.

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Cite This Study

Baguckaitė et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb6285696592c86ed133https://doi.org/10.1111/apa.70539
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