High myocardial PD-L1 expression is associated with greater disease severity and a higher risk of major adverse cardiotoxic events in immune checkpoint inhibitor-associated myocarditis.
Does high myocardial PD-L1 expression predict greater disease severity and higher risk of major adverse cardiotoxic events in patients with ICI-associated myocarditis?
Assessment of PD-L1 expression in endomyocardial biopsy specimens may serve as a prognostic marker to identify high-risk patients with ICI-associated myocarditis who may benefit from early intervention.
High myocardial PD-L1 expression is associated with greater disease severity and a higher risk of major adverse cardiotoxic events in ICI-associated myocarditis. Assessment of PD-L1 expression in endomyocardial biopsy specimens may help identify patients at high risk who may benefit from early intervention and closer monitoring.
Imaoka et al. (2026) studied this question. High myocardial PD-L1 expression is associated with greater disease severity and a higher risk of major adverse cardiotoxic events in immune checkpoint inhibitor-associated myocarditis.