What question did this study set out to answer?

To report two cases of bilateral atypical femoral fractures (AFF) due to long-term osteoporosis medication and the outcomes of preventive internal fixation.

April 24, 2026Orthopedics & Traumatology0 citationsOpen Access

骨粗鬆症治療薬の長期投与に伴い両側非定型大腿骨骨折を来し予防的内固定を行った2症例

貴福貴仁福田知田知法田畑

Key Points

To report two cases of bilateral atypical femoral fractures (AFF) due to long-term osteoporosis medication and the outcomes of preventive internal fixation.
Descriptive case analysis of two women with bilateral AFF after long-term treatment with osteoporosis medications.
Preventive internal fixation was performed with intramedullary nails on both sides.
Post-operative follow-up assessed recovery and activities of daily living (ADL).
Both patients underwent preventive fixation with intramedullary nails and began full weight-bearing walking the day after surgery.
Both demonstrated no decrease in ADL and experienced no postoperative pain during follow-up.
The surgical intervention led to a favorable recovery without complications in both cases.

Abstract

【背景】長期骨粗鬆症治療薬投与の合併症として非定型大腿骨骨折（Atypical femoral fracture：AFF）の報告が散見される．今回長期骨粗鬆症治療薬投与により両側AFFを来し予防的内固定を行った2症例を経験したため報告する．【症例】70歳女性，63歳時に骨転移を伴う左浸潤性乳管癌に対して左乳房部分切除，術後化学療法，ゾレドロン酸投与開始された．術後7年10ヶ月に右大腿部痛出現し，Xpで両側AFFと診断，両下肢免荷し両側髄内釘による予防的内固定を行った．76歳女性，自己免疫性肝炎に対するステロイド内服によりアレンドロン酸を9年内服していた．両側大腿部痛出現しXpで両側AFFと診断され，両側髄内釘での予防的内固定を行った．いずれも術翌日より全荷重で歩行を開始し受傷前と同程度のADLを獲得した．【結論】完全骨折に至る前に両側髄内釘による予防的内固定を行い術後良好な経過をたどった．両側ともに術後ADL低下や疼痛なく良好に経過している．

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Cite This Study

福田 et al. (2026) studied this question.

synapsesocial.com/papers/69eb08ef553a5433e34b3967 https://doi.org/10.5035/nishiseisai.75.240

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April 24, 2026Orthopedics & Traumatology0 citationsOpen Access

骨粗鬆症治療薬の長期投与に伴い両側非定型大腿骨骨折を来し予防的内固定を行った2症例

貴福貴仁福田知田知法田畑

Key Points

To report two cases of bilateral atypical femoral fractures (AFF) due to long-term osteoporosis medication and the outcomes of preventive internal fixation.
Descriptive case analysis of two women with bilateral AFF after long-term treatment with osteoporosis medications.
Preventive internal fixation was performed with intramedullary nails on both sides.
Post-operative follow-up assessed recovery and activities of daily living (ADL).
Both patients underwent preventive fixation with intramedullary nails and began full weight-bearing walking the day after surgery.
Both demonstrated no decrease in ADL and experienced no postoperative pain during follow-up.
The surgical intervention led to a favorable recovery without complications in both cases.

Abstract

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Cite This Study

福田 et al. (2026) studied this question.

synapsesocial.com/papers/69eb08ef553a5433e34b3967 https://doi.org/10.5035/nishiseisai.75.240

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