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April 24, 2026Hypertension0 citations

Hypertension Drives Protein Lactylation and Vascular Dysfunction in Skeletal Muscle

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MFMilene T. FontesPTPaul TownsendLBLandon Butler

Key Points

  • To understand how hypertension affects protein lactylation and vascular function in skeletal muscle.
  • Investigated the impact of hypertension on skeletal muscle metabolism
  • Analyzed protein lactylation levels in hypertensive conditions
  • Explored lactate-mediated signaling pathways
  • Hypertension leads to increased protein lactylation in skeletal muscle
  • Vascular dysfunction is linked to impaired muscle-vascular communication
  • Persistent lactate accumulation contributes to metabolic disturbances

Abstract

Hypertension disrupts skeletal muscle metabolic homeostasis and muscle-vascular communication, driven in part by persistent lactate accumulation and altered protein lactylation. Targeting lactate-mediated signaling may offer new therapeutic avenues for hypertensive vascular dysfunction.

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Cite This Study

Fontes et al. (2026) studied this question.

synapsesocial.com/papers/69eb09c9553a5433e34b41efhttps://doi.org/10.1161/hypertensionaha.125.25665
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