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April 24, 2026RSC Medicinal Chemistry0 citations

A new class of Indole-based HDAC8 inhibitors as potential anti-lung cancer agents: In silico design, synthesis, biological assessment and binding interaction analysis

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SKSamima KhatunJadavpur UniversityVMVenkatesh MuthukumarBirla Institute of Technology and Science - Hyderabad CampusAHAmbati HimajaBirla Institute of Technology and Science, Pilani

Key Points

  • The aim is to develop and assess a new series of indole-based HDAC8 inhibitors for lung cancer treatment.
  • Designed and synthesized indole-based hydroxamic acids
  • Conducted in silico analyses including QSAR and chemical space networks
  • Performed biological assessments to evaluate effectiveness against lung cancer
  • Identified several promising HDAC8 inhibitors with significant anti-cancer activity
  • Showed strong binding interactions with HDAC8
  • Demonstrated enhanced efficacy in preclinical models of lung cancer

Abstract

A novel series of indole-based hydroxamic acids was designed, synthesized, and evaluated as promising HDAC8 inhibitors for lung cancer therapy. In silico analyses, including classification-based QSAR, chemical space networks, and...

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Cite This Study

Khatun et al. (2026) studied this question.

synapsesocial.com/papers/69eb09ff553a5433e34b43c9https://doi.org/10.1039/d6md00194g
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