Infective endocarditis and precision medicine: A narrative review

Infective endocarditis (IE) remains a life-threatening condition with high global morbidity and mortality, demanding more effective strategies for early detection and management. Precision medicine offers a transformative approach, starting with comprehensive risk profiling that combines genetic predisposition, preexisting comorbidities, and lifestyle factors such as intravenous drug use and oral hygiene. This paradigm extends to point-of-care diagnostics and culminates in targeted, patient-specific treatment strategies. To explore its potential in IE, we systematically searched PubMed, Scopus, and Embase, identifying and synthesizing key literature into a narrative review. Our findings highlight precision medicine as a promising framework to enhance timely diagnosis and support individualized therapeutic decision-making in IE.