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April 25, 2026Immunological Investigations2 citations

Lactylation-Mediated METTL14 Promotes Glycolysis Through Facilitating PGAM1 m6A Methylation in Non-Small Cell Lung Cancer

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QWQibin WangGLGuangjun Liu

Key Points

  • This research aims to understand how lactylation influences METTL14 expression and its effects on glycolysis in non-small cell lung cancer (NSCLC).
  • Investigated the relationship between lactylation, METTL14, and PGAM1 m6A methylation in NSCLC cells.
  • Lactylation significantly enhanced METTL14 expression.
  • Increased METTL14 promoted PGAM1 m6A methylation, leading to enhanced glycolysis in NSCLC.

Abstract

Lactylation enhanced METTL14 expression, thereby promoting PGAM1 m6A methylation to facilitate glycolysis in NSCLC. This finding uncovers a novel metabolic regulatory axis and offers a potential therapeutic target for NSCLC intervention.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b2388ba6daa22dacad9https://doi.org/10.1080/08820139.2026.2662683
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