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April 26, 2026RSC Chemical Biology0 citationsOpen Access

De novo acyl carrier proteins display structure-independent modification and sequence novelty

MHMichael Andrés HerreraGKGrace KingZOZoe Ozols

Key Points

  • This research investigates the capabilities of de novo acyl carrier proteins and their unique modifications.
  • Engineered acyl carrier proteins with varying sequences, focusing on structural impact and modification techniques.
  • Conducted comparative analyses to assess functionality and versatility in metabolic processes.
  • Identified multiple sequence variations leading to successful modifications, enhancing acyl carrier protein functions.
  • Demonstrated that modifications could occur independently of the protein structure, suggesting novel engineering pathways.

Abstract

Acyl carrier proteins (ACPs) are dynamic, structurally conserved α-helical proteins central to many primary and secondary metabolic processes. Whilst prior engineering efforts have focused on strategic mutagenesis and “helix swaps”,...

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Cite This Study

Herrera et al. (2025) studied this question.

synapsesocial.com/papers/69edabdf4a46254e215b3ae2https://doi.org/10.1039/d5cb00148j
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