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July 24, 2025Annals of Surgery3 citations

Randomized Controlled: Trial of New Oral Anticoagulants Versus Warfarin for Postcardiac Surgery Atrial Fibrillation

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PMPhilicia MoonsamyYZYunong ZhaoAMAdham Makarem

Key Points

  • Evaluate the effectiveness of rivaroxaban compared to warfarin in patients with new-onset atrial fibrillation after cardiac surgery.
  • Randomized controlled trial design

Structured PICO

Does rivaroxaban reduce length of stay or improve patient experience compared to warfarin in patients with new-onset atrial fibrillation after cardiac surgery?

P
Population
Patients with new-onset atrial fibrillation after cardiac surgery
I
Intervention
Rivaroxaban
C
Comparator
Warfarin
O
Outcome
Length of stay

Rivaroxaban is a viable, more convenient alternative to warfarin for post-cardiac surgery atrial fibrillation, supporting its use in shared decision-making.

Abstract

Treatment with rivaroxaban in new-onset atrial fibrillation after cardiac surgery did not decrease length of stay compared with warfarin. However, patients treated with rivaroxaban reported significantly better convenience and a more favorable overall perception of their anticoagulation experience compared with warfarin. Given similar safety profiles, these findings support incorporating rivaroxaban as an option for shared decision-making when selecting anticoagulation therapy for this patient population.

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Cite This Study

Moonsamy et al. (2025) studied this question.

synapsesocial.com/papers/69eedeba0fb71af24d31153dhttps://doi.org/10.1097/sla.0000000000006853
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rationale and Design of the Randomized Controlled Trial of New Oral Anticoagulants Versus Warfarin for Post Cardiac Surgery Atrial Fibrillation2020 · 9 citations
  2. 2Early anti-coagulation therapy in new-onset atrial fibrillation after coronary artery bypass grafting: a randomized trial pilot study2024 · 3 citations
  3. 3Real-world comparative safety and effectiveness of rivaroxaban versus warfarin in patients with non-valvular atrial fibrillation: a prospective cohort study2026
  4. 4Risks of Stroke and Mortality in Atrial Fibrillation Patients Treated With Rivaroxaban and Warfarin2019 · 52 citations
  5. 5Efficacy and safety evaluation of rivaroxaban vs. warfarin among non-valvular atrial fibrillation patients undergoing lower extremity revascularization2022