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January 1, 1991European Journal of Cardio-Thoracic Surgery46 citations

Recurrent atrial arrhythmias following treatment for postoperative atrial fibrillation after coronary bypass operations

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RLR LANDYMOREFHF.R. Howell

Key Points

  • To determine the incidence of recurrent atrial arrhythmias following treatment for postoperative atrial fibrillation after coronary bypass operations.
  • Ambulatory Holter monitoring was performed in 58 patients post-myocardial revascularization.

Structured PICO

Does the duration of digoxin treatment affect the recurrence of atrial arrhythmias in patients with postoperative atrial fibrillation after coronary bypass?

P
Population
58 patients during early convalescence after coronary bypass operations, including 43 who developed spontaneous symptomatic postoperative atrial fibrillation requiring digitalization and 15 controls who did not develop spontaneous atrial fibrillation.
I
Intervention
Digoxin treatment continued for 8 weeks (n=16), 5 weeks (n=13), or 3 weeks (n=14) following operation.
C
Comparator
Patients without postoperative atrial fibrillation (n=15) and comparison between different durations of digoxin therapy (3, 5, or 8 weeks).
O
Outcome
Incidence of recurrent atrial arrhythmias (symptomatic and asymptomatic atrial fibrillation) assessed by 24-hour ambulatory Holter monitoring.surrogate

Digoxin therapy for postoperative atrial fibrillation after coronary bypass can be safely discontinued 3 weeks after the operation without significant recurrence of symptomatic atrial fibrillation.

Abstract

Ambulatory Holter monitoring was performed in 58 patients during the early convalescence after myocardial revascularization in order to determine the incidence of recurrent atrial arrhythmias following treatment for postoperative atrial fibrillation. Fifteen patients who had undergone coronary bypass and had not developed spontaneous atrial fibrillation following operation served as the controls (group 1). The remaining patients developed spontaneous symptomatic atrial fibrillation after coronary bypass that required digitalization for rate control. Sixteen patients (group 2) continued taking digoxin for 8 weeks following operation, 13 patients (group 3) discontinued digoxin treatment 5 weeks following operation, and 14 patients (group 4) discontinued digoxin treatment 3 weeks following operation. Twenty-four-hour Holter monitoring indicated that asymptomatic atrial fibrillation was common in the treatment groups after digitalization just before discharge from hospital. Atrial fibrillation, however, rarely recurred following discharge from hospital and was never symptomatic. Our data indicate that patients who develop spontaneous postoperative atrial fibrillation should be treated with digoxin for 3 weeks following operation and then drug therapy may be discontinued indefinitely.

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Cite This Study

LANDYMORE et al. (1991) studied this question.

synapsesocial.com/papers/69eedebca84321e0ae63c52ahttps://doi.org/10.1016/1010-7940(91)90191-l
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arrhythmias after coronary bypass surgery.1984 · 88 citations
  2. 2Atrial fibrillation after coronary artery bypass surgery: Possibilities of prevention2012 · 4 citations
  3. 3POST-OPERATIVE ATRIAL FIBRILLATION2015 · 5 citations
  4. 4Effect of intravenous diltiazem and digoxin on atrial fibrillation after on-pump coronary artery bypass surgery2004
  5. 5POST-OPERATIVE ATRIAL FIBRILLATION; INCIDENCE AFTER CORONARY ARTERY BYPASS GRAFT SURGERY2015