Is endothelium-dependent vasodilation attenuated in patients with heart failure?
Endothelium-dependent vasodilation is impaired in heart failure, potentially contributing to characteristic vasoconstriction abnormalities.
These data suggest that endothelium-dependent vasodilation is attenuated in patients with heart failure. Although the mechanisms of the decreased endothelium-dependent responses in heart failure are not known, this impaired local vasodilation may contribute to abnormalities in vasoconstriction that are characteristic of heart failure.
Kubo et al. (1991) studied this question.