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November 8, 2025Circulation1 citationsOpen Access

Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial

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JHJulian S. HaimovichSKShinwan KanyYCYuchiao Chang

Key Points

  • This research aims to investigate the incidence and outcomes of stressor-associated atrial fibrillation (AF) in primary care patients.
  • Analysis of AF events among over 30,000 primary care patients

Structured PICO

What are the incidence, risk factors, and outcomes of stressor-associated atrial fibrillation in primary care patients?

P
Population
>30 000 primary care patients with adjudicated atrial fibrillation (AF) events from the VITAL-AF Trial
O
Outcome
Incidence, risk factors, and outcomes (including oral anticoagulant initiation and adverse outcomes) of stressor-associated AF

Stressor-associated AF is common and carries similar risks to typical AF, yet is undertreated with oral anticoagulants, highlighting a significant gap in clinical management.

Abstract

Among >30 000 primary care patients with adjudicated AF events, nearly one-third of incident AF cases were stressor associated. Despite similar risk factor profiles and comparably high rates of adverse outcomes, oral anticoagulant initiation is lower when AF is stressor associated. Future work is needed to define optimal approaches to prevention, surveillance, and management of stressor-associated AF.

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Cite This Study

Haimovich et al. (2025) studied this question.

synapsesocial.com/papers/69eedf8ba84321e0ae63c7e8https://doi.org/10.1161/circulationaha.125.076421
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