PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 27, 2026Expert Opinion on Drug Discovery1 citations

Therapeutic targeting of adhesion GPCRs: a status update and future potential

View Full Paper
JSJesse D. StillwellUniversity of Alabama at BirminghamMEMaryam Ahmadian ElmiUniversity of Alabama at BirminghamRPRashed R. ParagUniversity of Alabama at Birmingham

Key Points

  • The aim is to address knowledge gaps regarding endogenous ligands and signaling pathways of adhesion GPCRs, facilitating their therapeutic exploitation.
  • Review existing literature on adhesion GPCRs and their signaling pathways.
  • Discuss the challenges in ligand identification and the implications for drug development.
  • Identifying endogenous ligands will enable the creation of a comprehensive library of agonists and antagonists.
  • Overcoming knowledge gaps is expected to lead to more effective therapeutic approaches targeting adhesion GPCRs in the coming years.

Abstract

The field is currently hampered by lack of knowledge about endogenous ligands and downstream signaling for aGPCRs. Once this knowledge gap is overcome, a clear library of agonists and antagonists can be developed, unleashing successful and widespread aGPCR exploitation and modulation. In the coming years, ligand identification will accelerate, allowing more aGPCR therapeutic advances.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Stillwell et al. (2026) studied this question.

synapsesocial.com/papers/69eefc6dfede9185760d379ehttps://doi.org/10.1080/17460441.2026.2662413
Ask AI
Helpful
Bookmark
Share
View Full Paper