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November 1, 2022Journal of the American College of Cardiology88 citationsOpen Access

Cardiovascular Risk Reduction After Renal Denervation According to Time in Therapeutic Systolic Blood Pressure Range

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FMFelix MahfoudGMGiuseppe ManciaRSRoland E. Schmieder

Structured PICO

Does higher time in therapeutic systolic blood pressure range after renal denervation reduce major cardiovascular events?

P
Population
Patients undergoing renal denervation in the Global SYMPLICITY Registry [GSR] DEFINE
I
Intervention
Renal denervation (RDN)
O
Outcome
Major cardiovascular events from 6 to 36 monthshard clinical

Higher time in therapeutic systolic blood pressure range after renal denervation is associated with a significant reduction in subsequent major cardiovascular events.

Abstract

There were sustained BP reductions and higher TTR through 36 months after RDN. A 10% increase in TTR through 6 months was associated with significant risk reductions in major cardiovascular events from 6 to 36 months. (Global SYMPLICITY Registry GSR DEFINE; NCT01534299).

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Mahfoud et al. (2022) studied this question.

synapsesocial.com/papers/69effb1a4f6a06657c21e2dahttps://doi.org/10.1016/j.jacc.2022.08.802
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