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March 1, 2005Journal of Clinical Investigation1,227 citationsOpen Access

Oxygen, oxidative stress, hypoxia, and heart failure

FGFrank J. Giordano

Key Points

  • To outline the complex physiological and pathological roles of oxygen, hypoxia, and reactive oxygen species in cardiac viability and the progression of heart failure.
  • Narrative synthesis of molecular pathways mediating oxygen regulation in cardiac tissue.
  • Evaluation of oxygen-dependent cardiac gene expression and reactive oxygen species generation mechanisms.
  • Oxygen supply is essential for maintaining cardiac viability but simultaneously drives the generation of reactive oxygen species (ROS).
  • Dysregulation in oxygen availability and oxidative signaling alters cardiac gene expression, promoting cellular dysfunction, tissue injury, and death.

Abstract

A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

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Cite This Study

Frank J. Giordano (2005) studied this question.

synapsesocial.com/papers/69f14bfac0d8017361865b94https://doi.org/10.1172/jci200524408
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