Why the study?
Does shear stimulus area under the curve (AUC) or peak shear rate determine the magnitude of flow-mediated dilation in healthy males?
Population
10 healthy males for the duration manipulation experiment and 8 healthy males for the peak manipulation…
Comparison
Reactive hyperemia duration manipulation and… vs Different durations and peak shear rates within…
Design
Other
Authors
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Requires accounting for shear AUC when interpreting FMD; leaves open relevance to patient populations.
Does shear stimulus area under the curve (AUC) or peak shear rate determine the magnitude of flow-mediated dilation in healthy males?
Shear stimulus area under the curve, rather than peak shear rate, is the critical determinant of peak flow-mediated dilation response.
Pyke et al. (2006) studied this question.