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April 30, 2026Infectious Agents and Cancer0 citationsOpen Access

Immune Tolerance in Hepatocellular Carcinoma: Impact of Liver Diseases and Therapeutic Insights

Regulation of immune tolerance in hepatocellular carcinoma by liver diseases: a review

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Authors

JLJinyi LiYLYuanda Liu

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Overview

Review explores immune tolerance mechanisms in hepatocellular carcinoma, indicating that liver diseases affect T cell exhaustion and immunotherapy responses.

Key Points

  • To discuss how various liver diseases influence immune tolerance in hepatocellular carcinoma and guide treatment strategies.
  • Systematic review of mechanisms by which liver diseases affect immune microenvironment in HCC.
  • Evaluation of chronic liver conditions like metabolic dysfunction, viral hepatitis, and alcoholic liver disease.
  • Assessment of synergistic effects of treatments such as lipid-lowering and antiviral drugs on HCC therapies.
  • Identified immune tolerance mechanisms that limit HCC response to immune checkpoint inhibitors.
  • Highlighted the role of chronic liver diseases in promoting T cell exhaustion and immunosuppressive cells.
  • Explored potential benefits of combining drugs for underlying liver diseases to enhance immunotherapy efficacy in HCC.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4b78c0f03fd67763c44https://doi.org/10.1186/s13027-026-00764-5
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