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April 30, 2026Cureus0 citationsOpen Access

Thyroid Eye Disease, Glycemic Control, and the Role of a One-Stop Clinic Approach: A Retrospective Audit Study

KCKeiko CarterZKZahid KhanBMBashir Mahamud

Key Points

  • This audit aims to evaluate glycemic control among thyroid eye disease patients receiving glucocorticoids at a specialized clinic.
  • Retrospective audit of 221 patients attending an ophthalmology-led TED clinic from January 2018 to June 2024.
  • Included analysis of baseline and follow-up fasting glucose levels in a subgroup of 29 patients receiving glucocorticoids.
  • Data extraction from electronic and paper medical records.
  • Documentation of baseline fasting glucose levels was available in 41.4% (12 of 29) steroid-treated patients.
  • Follow-up fasting glucose levels were recorded in 17.2% (5 of 29) of patients after glucocorticoid treatment.
  • Only 13.8% of glucocorticoid-treated patients had pre-existing diabetes, highlighting the risk of steroid-induced hyperglycemia.

Abstract

Background: Thyroid eye disease (TED) is a serious medical condition observed in patients with thyroid disorders, and patients often present in emergencies, threatening their vision. Methodology: This retrospective audit was conducted at Queens Hospital, Romford, and included patients with TED who attended a dedicated ophthalmology-led TED clinic between January 2018 and June 2024. A total of 221 patients were included in this study, and their data were extracted from electronic and paper medical records, including clinic letters. Baseline and post-treatment glycemic monitoring was incompletely documented among steroid-treated patients (n=29). Baseline fasting glucose levels prior to steroid initiation were documented in 12 of 29 (41.4%) patients, and follow-up fasting glucose levels after steroid completion were documented in five of 29 (17.2%) patients. Results: This study included 221 patients who visited the ophthalmology-led TED clinic between January 2018 and June 2024. The study cohort comprised 69% female and 31% male patients, with a mean age of 56.52 years (range, 22-92 years). Of the overall cohort, 29 patients (13.1%), aged 29-85 years, who received oral or intravenous systemic glucocorticoids for TED, were included in the main analysis group. Within this subgroup, four of 29 patients (13.8%) had pre-existing diabetes. Conclusion: Glucose and HbA1c monitoring during systemic glucocorticoid therapy in patients with TED at this center was incomplete and fell below evidence-based recommendations, despite the recognised risk of steroid-induced hyperglycemia and new-onset diabetes with high-dose steroid exposure. There is a need for more standardised and improved care for patients with TED presenting to outpatient clinics. We recommend setting up a “one-stop” TED clinic to provide standardised care.

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Cite This Study

Carter et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0991e5f7920c6386cd5https://doi.org/10.7759/cureus.107831
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