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April 30, 2026International Journal of Infectious Diseases0 citationsOpen Access

Successful Treatment of Balamuthia Mandrillaris Amebic Encephalitis Diagnosed by MetaCAP in China: A Case Report and Review of 25 Survival Cases

YZYuanwen ZhangJXJi XiaZQZengyun Qiu

Key Points

  • To highlight effective strategies for diagnosing and treating Balamuthia amebic encephalitis.
  • Case report on the use of MetaCAP for diagnosis
  • Review of 25 survival cases with various treatment strategies
  • Discussion on the role of steroids and sulfasalazine in treatment
  • Combination therapy and surgery led to improved survival in Balamuthia amebic encephalitis cases.
  • Steroids were found not recommended for treatment.
  • Sulfasalazine identified as a potential adjuvant anti-inflammatory treatment.

Abstract

Early identification and diagnosis are key to curing Balamuthia amebic encephalitis.MetaCAP represents a vital tool for the early diagnosis of unexplained encephalitis.Combination therapy and surgery improve BAE survival; steroids not recommended.Sulfasalazine may be considered as an adjuvant anti-inflammatory treatment for BAE.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0991e5f7920c6386ceehttps://doi.org/10.1016/j.ijid.2026.108745
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