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April 30, 2026Inorganic Chemistry0 citations

Rational Design and Development of an Acyclic Chelator H 4 pyox for Theranostic Radiometal Labeling under Mild Conditions

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JYJian YanChinese Academy of Medical Sciences & Peking Union Medical CollegeJYJingjing YaoCentral South UniversityYQYu QiuChinese Academy of Medical Sciences & Peking Union Medical College

Key Points

  • The aim is to develop an acyclic chelator, H4pyox, for effective radiometal labeling in radiopharmaceuticals.
  • Designed and synthesized acyclic chelator H4pyox.
  • Assessed its labeling efficiency under mild conditions.
  • Evaluated pharmacokinetic properties for various targeting vectors.
  • H4pyox exhibits enhanced radiometal labeling efficiency compared to previous chelators.
  • Improved pharmacokinetic properties were noted for radiopharmaceuticals targeting vectors with low thermal stability.

Abstract

pyox for radiopharmaceutical development and provide a complementary choice in the design of metal-based radiopharmaceuticals and in the tuning of their pharmacokinetic properties─especially for targeting vectors with poor thermal stability.

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Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0e31e5f7920c6386d7bhttps://doi.org/10.1021/acs.inorgchem.5c05511
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