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April 30, 2026Journal of Medicinal Chemistry0 citations

Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders

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WTWojciech TrybałaKGKatarzyna GrychowskaNMNatalia Malikowska‐Racia

Key Points

  • This research focuses on enhancing the design and efficacy of dually acting ligands targeting serotonin receptors in CNS disorders.
  • Integrated structure-activity insights and clinical findings to guide ligand design.
  • Explored biased signaling and optopharmacology for developing innovative dually acting agents.
  • Advances in biased signaling may improve the binding efficacy of dually acting ligands.
  • Utilizing photochromic ligands shows potential for enhanced safety profiles in CNS treatments.

Abstract

receptors ligands. Integrating structure-activity insights and clinical findings, we discuss challenges of rational dual modulation. Advances in biased signaling, targeting distinctive conformational states, and optopharmacology utilizing photochromic ligands may further enable the design of innovative dually acting agents with improved efficacy and safety profiles.

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Cite This Study

Trybała et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0e31e5f7920c6386da7https://doi.org/10.1021/acs.jmedchem.5c03094
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