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May 2, 20261 citations

Bioresponsive Release and Multiple Signal Amplification Induce a Strong Signal-On Mode for Hydrocortisone Ultrasensitive Detection.

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ZHZiqiu HuangLZLu ZhaoXSXianzhen Song

Key Points

  • This research aims to enhance the sensitivity of hydrocortisone detection through bioresponsive signal amplification.
  • Developed a sensor utilizing multiple signal amplification for detection.
  • Assessed the analytical performance of the sensor using a dynamic range from 100 fg/mL to 1 μg/mL.
  • Determined the limit of detection (LOD) at 25.3 fg/mL.
  • Achieved excellent analytical performance across a broad dynamic range.
  • Demonstrated a low LOD of 25.3 fg/mL for hydrocortisone detection.
  • Induced a strong signal-on mode significantly increasing sensor sensitivity.

Abstract

to further increase the ECL signal change. Overall, the strong signal-on mode induced via multiple signal amplification can improve the sensitivity of the sensor. The resulting sensor showed excellent analytical performance with a broad dynamic range from 100 fg/mL to 1 μg/mL. The low limit of detection (LOD) was 25.3 fg/mL. This design provided a new direction for ultrasensitive monitoring of HC in the environment.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69f593f271405d493affed45https://doi.org/10.1021/acs.analchem.5c07347
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