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Synapse
May 2, 20260 citations

Gut microbiota composition and tumor immune features in meningioma patients.

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KYKai YinSMShuai MaJYJichao Yang

Key Points

  • This research aims to investigate the relationship between gut microbiota composition and tumor immune features in meningioma patients.
  • Analyzed gut microbiota composition in meningioma patients
  • Examined levels of immune cell infiltration (neutrophils, macrophages, T cells) in tumor samples
  • Correlated microbiota signature with immune features present in the tumor
  • Increased abundance of Enterobacteriaceae was correlated with higher intratumoral MPO⁺ neutrophils, CD68⁺ macrophages, and CD3⁺ T cells
  • Establishment of a microbiome signature linked to tumor inflammation
  • Suggests potential for using gut microbiota as a biomarker for meningioma inflammation

Abstract

dominance and depletion of immunomodulatory commensals. This signature correlates with increased immune infiltration and holds promise as a novel biomarker. IMPORTANCE: /Enterobacteriaceae abundance and increased intratumoral infiltration of MPO⁺ neutrophils, CD68⁺ macrophages, and CD3⁺ T cells. These findings are the first evidence that gut microbiome dysbiosis is closely associated with meningioma inflammation.

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Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/69f594fc71405d493afffdfahttps://doi.org/10.1128/spectrum.02485-25
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