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April 28, 1998CirculationOpen Access

Improvement of Repolarization Abnormalities by a K + Channel Opener in the LQT1 Form of Congenital Long-QT Syndrome

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Why the study?

Does nicorandil improve epinephrine-induced repolarization abnormalities in patients with the LQT1 form of congenital long-QT syndrome?

Population

6 patients with a congenital form of LQT1 syndrome with KvLQT1 defect and 8 control patients

Comparison

Nicorandil administered during epinephrine… vs Baseline/epinephrine-only state, and control…

Design

Case-control

Authors

WSWataru ShimizuTKTakashi KuritaKMKiyotaka Matsuo

Discussion

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Overview

Hypothesis-generating for nicorandil in LQT1; prospective trials needed before clinical adoption.

Structured PICO

Does nicorandil improve epinephrine-induced repolarization abnormalities in patients with the LQT1 form of congenital long-QT syndrome?

P
Population
6 patients with a congenital form of LQT1 syndrome with KvLQT1 defect and 8 control patients
I
Intervention
Nicorandil (a K+ channel opener) administered during epinephrine infusion
C
Comparator
Baseline/epinephrine-only state, and control patients without LQT1
O
Outcome
Repolarization parameters including QT interval, 90% monophasic action potential duration (MAPD90), dispersion of MAPD90, early after depolarizations (EADs), and ventricular premature complexes (VPCs)surrogate

Nicorandil, a K+ channel opener, improves epinephrine-induced repolarization abnormalities in patients with the LQT1 form of congenital long-QT syndrome.

Cite This Study

Shimizu et al. (1998) studied this question.

synapsesocial.com/papers/69f69138e405cc4465bc2ac1https://doi.org/10.1161/01.cir.97.16.1581
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