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May 3, 20260 citations

Imaging-Guided Photodynamic Control of Autophagy-Apoptosis in Breast Cancer

Imaging-guided photodynamic control of autophagy-apoptosis switching in breast cancer using hypericin-functionalized upconverting nanoparticles.

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Authors

VHVeronika HuntošováTVTaras VasylyshynVPVitalii Patsula

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Overview

Randomized trial shows enhanced control of autophagy-apoptosis in breast cancer, indicating improved treatment selectivity.

Key Points

  • This research aims to explore the efficacy of hypericin-functionalized upconverting nanoparticles for controlling autophagy and apoptosis in breast cancer.
  • Developed UCNPs functionalized with cyanine dye and hypericin for dual therapy and bioimaging.
  • Evaluated nanoparticle uptake and distribution in SKBR3 breast cancer cells using confocal and fluorescence lifetime imaging.
  • Assessed light-induced effects on autophagy and apoptosis through biochemical assays including Western blot and caspase-3 activation.
  • Nanoparticles effectively transported photosensitizers into cells, enabling precise control of photodynamic effects.
  • Light irradiation resulted in a distinct switch between autophagy and apoptosis based on specific nanoparticle formulations.
  • Enhanced lymphatic targeting was confirmed, indicating improved therapeutic selectivity in breast cancer treatment.

Cite This Study

Huntošová et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5308071d4f1bdfc5f41https://doi.org/10.1016/j.jconrel.2026.114961
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