Chondrosarcoma is one of the most common primary malignant bone tumors in adults, with a predilection for sites such as the pelvis and femur. This article reports a rare case of giant chondrosarcoma originating from the manubrium sterni in a 42-year-old male patient. The patient presented to the outpatient clinic with chest pain accompanied by chest wall swelling. Physical examination revealed a firm mass at the manubrium, and chest CT demonstrated osteolytic destruction of the sternum. Needle biopsy pathology was suggestive of chondrosarcoma. A multidisciplinary team performed a radical resection of the sternal tumor. The postoperative outcome was favorable, with a stable thoracic cage. Histopathological examination confirmed the diagnosis of grade II chondrosarcoma.
Zhu et al. (2026) studied this question.