PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 3, 20260 citations

Stereocontrolled spirocyclization of exo-glycals with arylamines for the synthesis of (1S)-spiro-tetrahydroquinoline glycosides.

View Full Paper
PCPo‐Yen ChenYCYi‐Ting ChiangCLChun-Hung Lin

Key Points

  • This research aims to develop a stereocontrolled method for synthesizing spiro-tetrahydroquinoline glycosides from glycals and arylamines.
  • Utilized ester-substituted anilines and sterically congested amino compounds in the synthesis process.
  • Focused on creating SGLT2 inhibitor tofogliflozin mimics through this approach.
  • Successfully synthesized spiro-4-tetrahydroquinoline glycosides exhibiting structural similarities to SGLT2 inhibitors.

Abstract

- and ester-substituted anilines, as well as sterically congested 1-aminoanthraquinone and 4-benzylaniline, for the synthesis of spiro-4-tetrahydroquinoline glycosides as SGLT2 inhibitor tofogliflozin mimics.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5618071d4f1bdfc602chttps://doi.org/10.1039/d6ob00392c
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes2008 · 632 citations
  2. 2Transformation of zinc hydroxide chloride monohydrate to crystalline zinc oxide2016 · 93 citations
  3. 3Design of Paromomycin and Neomycin as Sulfated and Hydrophobic Glycans to Target Heparanase-Driven Tumor Progression and Metastasis2025 · 9 citations
  4. 4Zinc Chloride Mediated Nucleophilic Substitution: Amination and Thioetherification of Alcohols at Room Temperature2020 · 9 citations
  5. 5Synthesis and Uses of exo-Glycals2003 · 149 citations