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Synapse
May 3, 20260 citations

Macrophage-Mediated In Vivo Intracellular Crystallization of Aluminum Oxyhydroxide Adjuvant in Vaccine-Induced Granulomas.

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EPEstela PérezMNM a José Gavara NavarroAIAlfonso Ibarra

Key Points

  • To examine how macrophages mediate the intracellular crystallization of aluminum oxyhydroxide adjuvant in vaccine-induced granulomas.
  • Investigated the role of macrophages in crystallization processes
  • Utilized in vivo models for observation of immune responses
  • Analyzed induration of vaccine-induced granulomas
  • Showed enhanced macrophage activity correlating with higher crystallization rates
  • Identified significant implications for vaccine adjuvant safety and efficacy
  • Revealed potential impacts on immunotoxicological responses

Abstract

, with potential industrial applications as well as relevance to immunotoxicology, pathology, and cell biology in the context of vaccine adjuvants.

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Cite This Study

Pérez et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5ac8071d4f1bdfc6412https://doi.org/10.1021/acsami.6c04089
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