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May 3, 2026RSC Chemical Biology1 citationsOpen Access

Prochelators modulate azole activity against Candida albicans in a metal-dependent manner

MMMadeline Ann MerrimanCDCatherine A. Denning-JannaceAHAndrea Barboza Hurtado

Key Points

  • To investigate how prochelators affect the efficacy of azoles against Candida albicans through copper modulation.
  • Assess the impact of prochelators on azole activity against Candida albicans
  • Measure copper accumulation in fungal cells
  • Evaluate fungicidal effects under various copper conditions.
  • Prochelators significantly increase copper levels in Candida albicans, enhancing azole activity
  • Demonstrated fungicidal effects under copper accumulation conditions, with a notable increase in efficacy.

Abstract

promotes copper accumulation under otherwise non-toxic copper conditions, resulting in fungicidal activity.

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Cite This Study

Merriman et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5ac8071d4f1bdfc64e0https://doi.org/10.1039/d6cb00073h
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