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May 3, 20260 citations

Self-Assembly Regulation, Drug Release Behavior, Anti-Multidrug Resistance of Redox-Responsive Gemcitabine-Quinine Nanoassemblies in Glioblastoma Therapy.

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JZJiayi ZuoChina Pharmaceutical UniversitySQShuhui QuChina Pharmaceutical UniversityHLHaoping LongChina Pharmaceutical University

Key Points

  • The aim is to evaluate the effectiveness of redox-responsive gemcitabine-quinine nanoassemblies in overcoming multidrug resistance in glioblastoma treatment.
  • Evaluated drug release behavior and toxicity of GQ-S NPs in U251 cells.
  • Assessed apoptotic effects and P-gp expression suppression in treated cells.
  • Measured intracellular gemcitabine levels to determine accumulation effects.
  • GQ-S NPs reduced P-gp expression and increased intracellular gemcitabine levels significantly.
  • GQ-S NPs showed lower cytotoxicity compared to free gemcitabine and conventional nanoassemblies.
  • The design achieved a substantial improvement in targeted therapy due to its low toxicity and high stability.

Abstract

of 1.560 ± 0.123 μM in U251 cells─7-fold and 2.7-fold lower than that of free Gem and GQ-C NPs, respectively. Mechanistic studies revealed that GQ-S NPs induced apoptosis and markedly suppressed P-gp expression, and promoted intracellular Gem accumulation. In summary, GQ-S NPs integrate the advantages of carrier-free design, low toxicity, high stability, and redox-responsive release, offering a promising strategy for targeted combination therapy in drug-resistant glioblastoma.

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Cite This Study

Zuo et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5ac8071d4f1bdfc64eahttps://doi.org/10.1021/acs.langmuir.5c06575
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