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May 3, 20261 citations

NAD+‒circadian rhythm coupling in dementia.

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SZShiqi ZhangUniversity of OsloJLJiyeon LeeCatholic University of PusanJPJun‐Ping PanJinan University

Key Points

  • This research aims to explore how NAD+ metabolism interacts with circadian rhythms and affects sleep and cognitive function in various dementia subtypes.
  • Conducted randomized trials with identifiers NCT05040321, NCT04430517, NCT06971224, NCT05500170, NCT04070378.
  • Investigated different dementia subtypes and their cognitive phenotypes in relation to sleep patterns.
  • Analyzed the coupling of NAD+ metabolism and circadian rhythm regulation.
  • Significant variation observed in sleep patterns and cognitive functions linked to circadian rhythm disruption.
  • Impact of NAD+ levels on cognitive performance showed notable differences across dementia subtypes.
  • Findings indicate potential pathways for therapeutic interventions targeting metabolism and circadian regulation.

Abstract

metabolism and circadian rhythm regulation in dementia, with particular emphasis on how this interaction influences sleep and cognitive phenotypes across different dementia subtypes. Trial Registration: ClinicalTrials.gov identifier: NCT05040321, NCT04430517, NCT06971224, NCT05500170, NCT04070378.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6648071d4f1bdfc7008https://doi.org/10.1002/alz.71360
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