Proton pump inhibitors, such as esomeprazole, are used to treat peptic ulcers and other stomach issues. Roughly 4 percent of people have peptic ulcers. In 2013, they were first observed in about 53 million people. Peptic ulcers affect 10% of persons at some point in their lives. Compared to 327,000 deaths in 1990, they caused 301,000 deaths in 2013. Princess Henrietta of England was the first person to be reported to have a ruptured peptic ulcer in 1670. Barry Marshall and Robin Warren discovered that H. pylori were the cause of peptic ulcers in the late 20th century; they were awarded the Nobel Prize in 2005 for this finding. Esomeprazole is classified as a non-surgical method of treating peptic ulcers. The enhanced version of omeprazole, known as s-isomer of omeprazole or esomeprazole, has some side effects in addition to its effectiveness in treating peptic ulcers. These side effects include headache, nausea, diarrhea, and decreased appetite. An assessment of the available research on the concurrent use of esomeprazole is given in this review article. This regimen's effectiveness, safety, tolerability, cost-effectiveness, and patient quality of life are examined. The mechanism of action of omeprazole, its effects during pregnancy, and a synopsis of its pharmacokinetic and pharmacodynamic interactions are also covered. An assessment of the available research on the concurrent use of esomeprazole is given in this review article. This regimen's effectiveness, safety, tolerability, cost-effectiveness, and patient quality of life are examined. The mechanism of action of omeprazole, its effects during pregnancy, and a synopsis of its pharmacokinetic and pharmacodynamic interactions are also covered.
Ansari et al. (2026) studied this question.