Vagus nerve stimulation paired with tones alters the expression of proteins regulating synaptic vesicles and transmission in the auditory cortex of a rat model of Rett syndrome.
Does Vagus Nerve Stimulation paired with tones alter the auditory cortex proteome in a rat model of Rett syndrome?
VNS paired with tones alters protein expression related to synaptic transmission in the auditory cortex of a Rett syndrome rat model, suggesting a potential mechanism for addressing auditory processing dysfunction.
rats by changing the expression of proteins involved in regulating synaptic vesicles and synaptic transmission. This work provides evidence of key mechanisms that may drive auditory processing dysfunction in Rett syndrome and demonstrates that VNS-tone pairing is sufficient to alter protein expression in the auditory cortex.
Myers et al. (2026) studied this question. Vagus nerve stimulation paired with tones alters the expression of proteins regulating synaptic vesicles and transmission in the auditory cortex of a rat model of Rett syndrome.
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