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July 24, 2013JAMA Internal MedicineOpen Access

In-Hospital and 1-Year Mortality in Patients Undergoing Early Surgery for Prosthetic Valve Endocarditis

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Why the study?

Does early valve replacement reduce in-hospital and 1-year mortality in patients with prosthetic valve endocarditis compared to medical therapy alone?

Population

1025 patients hospitalized with definite right- or left-sided prosthetic valve endocarditis enrolled in a…

Comparison

Valve replacement during index hospitalization vs Medical therapy alone

Design

Cohort

Follow-up

1 year

Authors

TLTahaniyat Lalani

Discussion

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Overview

Early surgery should not yet change practice in prosthetic valve endocarditis; leaves open possible benefit in highest-propensity subgroups.

Structured PICO

Does early valve replacement reduce in-hospital and 1-year mortality in patients with prosthetic valve endocarditis compared to medical therapy alone?

P
Population
1025 patients hospitalized with definite right- or left-sided prosthetic valve endocarditis (PVE) enrolled in a prospective, multinational, observational cohort
I
Intervention
Valve replacement during index hospitalization (early surgery)
C
Comparator
Medical therapy alone
O
Outcome
In-hospital and 1-year mortalityhard clinical

In patients with prosthetic valve endocarditis, early valve replacement was not associated with improved survival compared to medical therapy after adjusting for survival bias, though benefit was seen in subgroups with the highest surgical propensity.

Cite This Study

Tahaniyat Lalani (2013) studied this question.

synapsesocial.com/papers/69f788db68dd2736bfe202f6https://doi.org/10.1001/jamainternmed.2013.8203
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