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November 29, 2017Clinical Microbiology Reviews229 citationsOpen Access

Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies

HKHamed Haddad KashaniMSMathias SchmelcherHSHamed Sabzalipoor

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Abstract

. LysK is one of the best-characterized endolysins with activity against multiple staphylococcal species. Various approaches to further enhance the antibacterial efficacy and applicability of endolysins have been demonstrated. These approaches include the construction of recombinant endolysin derivatives and the development of novel delivery strategies for various applications, such as the production of endolysins in lactic acid bacteria and their conjugation to nanoparticles. These novel strategies are a major focus of this review.

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Kashani et al. (2017) studied this question.

synapsesocial.com/papers/69f876dad5e47b74b27a3528https://doi.org/10.1128/cmr.00071-17
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