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May 6, 2026RSC Medicinal Chemistry0 citations

Design, synthesis, and biological evaluation of novel SN38-sulfonamide conjugates as Topo I/CA IX dual inhibitors inducing ferroptosis in colorectal cancer

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XZXinyu ZhaoAYAnna YeYWYujie Wang

Key Points

  • This research aims to develop SN38-sulfonamide conjugates that act as dual inhibitors for colorectal cancer therapy.
  • Designed and synthesized SN38-sulfonamide conjugates
  • Conducted biological evaluation of the inhibitors
  • Performed structure-activity relationship analysis
  • Novel dual inhibitors target Topo I and CA IX
  • Conjugates induce ferroptosis in colorectal cancer models
  • Demonstrated potential therapeutic effects against cancer

Abstract

A series of novel SN38-sulfonamide conjugates were designed and synthesized as carbonic anhydrase IX (CA IX) and topoisomerase I (Topo I) dual inhibitors for colorectal cancer therapy. Structure-activity relationship analysis...

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b530fdahttps://doi.org/10.1039/d6md00290k
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