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May 6, 20260 citationsOpen Access

Formulation and Characterization of Stomach Specific Drug Delivery System of Nizatidine

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PJPraveen Nagar*, Neeraj Patidar, Dr. Abhishek Jain

Key Points

  • The aim is to characterize a stomach-specific drug delivery system for nizatidine using floating technology.
  • Formulation of a floating drug delivery system (FDDS) for nizatidine.
  • Characterization of the formulation based on buoyancy and drug release profiles.
  • Evaluation of bulk density in relation to gastric fluids.
  • The system maintains buoyancy in gastric fluids without affecting gastric emptying.
  • Characterization confirms a controlled and slow release of nizatidine in gastric contents.

Abstract

Floating drug delivery systems (FDDS) or hydro-dynamically balanced systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the stomach. After the release of the drug, the residual system is emptied from the stomach.

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Praveen Nagar*, Neeraj Patidar, Dr. Abhishek Jain (2026) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b532f58https://doi.org/10.5281/zenodo.20021506
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