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May 6, 2026Scandinavian Journal of Surgery1 citationsOpen Access

Survival of patients with complete metabolic response on 18 FFDG PET/CT after chemotherapy prior to transplantation for colorectal liver metastases

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NSNadide Mutlukoca SternSDSvein DuelandPLPål-Dag Line

Key Points

  • This research examines survival outcomes based on metabolic response assessed by FDG PET/CT after chemotherapy.
  • Patients with complete metabolic response on FDG PET/CT were identified.
  • Stratification of patients was done based on metabolic tumor volume: MTV 0, low, and high.
  • Survival outcomes including DFS, OS, and PRS were compared using Kaplan-Meier and log-rank tests.
  • FDG PET/CT indicated intermediate progression-free survival following chemotherapy for colorectal liver metastases.
  • Significant differences in DFS and OS were found when comparing MTV levels, particularly in the low and high groups.

Abstract

BACKGROUND AND AIMS: F]FDG PET/CT after chemotherapy, with patients presenting with low or high metabolic tumor volume (MTV). METHODS: F]FDG PET/CT, and patients with CMR (MTV = 0) were identified. Patients were stratified into three subgroups: MTV 0, MTV low, and MTV high. DFS, OS, and PRS were compared using the Kaplan-Meier method and the log-rank test. Baseline characteristics and CT reassessment data were analyzed using the Mann-Whitney U test for continuous variables and Fisher's exact test for categorical variables. RESULTS: = 0.010 and <0.001), including after exclusion of the MTV high group (0.034 and <0.001). CONCLUSION: F]FDG PET/CT after chemotherapy prior to liver transplantation for CRLM had intermediate DFS, OS, and PRS compared with patients with low and high MTV.

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Cite This Study

Stern et al. (2026) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b533028https://doi.org/10.1177/14574969261438696
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