Background: The study aimed at the postobturation pain and healing of chronic apical periodontitis by the use of AH plus and Endosequence BC. Materials and Methods : A total of 44 patients with chronic apical periodontitis were enrolled in this double-blinded randomized clinical trial, randomly divided into two groups: Group I (AH Plus sealer) and Group II (Endosequence BC sealer). After root canal treatment and obturation, healing was evaluated at 1 and 3 months using radiographs and OsiriX Lite software. Pain levels were recorded before treatment and 24 h postoperatively using a 10-point Modified Verbal Descriptor Scale. Statistical analysis using an independent t -test compared pain scores and healing progress between the two groups at each time point. Results: Pain reduction (%) and lesion size in both groups were analyzed using an independent t -test. The EndoSequence BC Sealer group showed significantly greater pain reduction at 24 h ( P 0.05). Lesion size showed no significant difference between groups at baseline, 1 month, and 3 months. However, Group II exhibited significant lesion size reduction from baseline to 1 month and 3 months ( P < 0.05). Conclusion: Within the limitations of the study, initial pain reduction was observed in the bioceramic sealer. However, single-sitting root canal therapy for chronic apical periodontitis was performed without any failures being noted.
Antony et al. (2026) studied this question.