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May 6, 2026Clinical Psychological Science0 citations

Exploring Transdiagnostic Mechanisms of Externalizing Psychopathology among Youths: A Longitudinal, Person-Centered Approach

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JSJessica N. SmithSCStefany CoxeMJMorgan L. Jusko

Key Points

  • To explore the relationship between executive functioning and the developmental course of externalizing psychopathology among youths.
  • Utilized the Oregon ADHD-1000 data set for exploratory data analysis.
  • Conducted multinomial logistic regressions on executive functioning domains.
  • Applied latent transition analysis to determine symptomatic classes and pathways.
  • Hyperactivity/impulsivity strongly linked to impairments in multiple executive functioning domains.
  • Inattention influenced set-shifting and processing speed impairments specifically.
  • Distinct patterns emerged for youth transitioning from hyperactivity/impulsivity in childhood to inattention in adolescence.

Abstract

In the present study, we used an exploratory data-analysis approach to consider how executive functioning (EF) relates to the developmental course of externalizing psychopathology using the Oregon ADHD-1000 data set. Multinomial logistic regressions of EF domains (working memory, processing speed, set shifting, reaction-time variability, response inhibition, and vigilance) in predicting symptomatic classes and longitudinal pathways from a recent latent transition analysis were conducted; predicted probability figures were interpreted. Findings suggest that hyperactivity/impulsivity (HI) was most related to EF impairment in many domains. Inattention contributed to set-shifting and processing-speed impairment specifically. HI and oppositionality were very aligned with one another in childhood and diverged in adolescence. Youths who were HI in childhood and inattentive in adolescence were distinct in EF impairment from youths who were inattentive across development. Findings reiterate the importance of exploratory, person-centered, longitudinal approaches for understanding heterogeneity, comorbidity, and developmental psychopathology.

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Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/69faa2e204f884e66b5336f9https://doi.org/10.1177/21677026251401554
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