PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
December 1, 1950Circulation18 citationsOpen Access

The Lewis A. Conner Lecture of the American Heart Association

View Full Paper
ABArthur L. Bloomfield

Key Points

  • Review the pathological principles of bacterial endocarditis to optimize antibiotic dosing strategies and achieve permanent bacteriologic cure.
  • Reviewed clinical and pathological features of bacterial endocarditis influencing antibiotic efficacy and time-dose relationships.
  • Evaluated the utility of strain sensitivity testing and newer antimicrobial regimens for managing resistant infections.
  • Bacterial strain sensitivity testing provides key guidance for determining effective daily antibiotic dosage.
  • Antibiotic therapy must be maintained continuously for at least one month to secure permanent bacteriologic eradication.
  • Specialized therapeutic strategies and newer agents are required to overcome highly resistant bacterial strains and complications.

Abstract

Some considerations concerning the fundamental pathology of bacterial endocarditis which have a bearing on treatment are discussed. In using antibiotics the importance of time-dose relationships is emphasized. It is pointed out that tests for strain sensitivity give a useful clue to the total daily dosage but that regardless of this, treatment must be carried out over a period of at least a month in order to achieve permanent bacteriologic cures. The difficulties and complications of treatment are discussed. Special methods for the treatment of highly resistant strains and the results with some of the newer antibiotics are outlined.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Arthur L. Bloomfield (1950) studied this question.

synapsesocial.com/papers/69fbd7cd6c3a0c248625dd64https://doi.org/10.1161/01.cir.2.6.801
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibacterial therapy for infective endocarditis: сurrent approaches and prospects2025
  2. 2The new American Heart Association guidelines on the prevention of infective endocarditis: culmination of a long process of thought2008 · 5 citations
  3. 3Practical approaches to antimicrobial therapy for infective endocarditis in the context of national and European clinical guidelines2024 · 1 citations
  4. 4Prevention of Bacterial Endocarditis1985 · 73 citations
  5. 5INFECTIVE ENDOCARDITIS IN ADULTS2002 · 78 citations