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May 7, 2026Pediatric Allergy and Immunology0 citations

Medium‐term pulmonary outcomes (<6 months) after pediatric COVID‐19 infection evaluated using impulse oscillometry and spirometry

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SBSimge Atar BeşeAMAdnan MercanZKZeynep Güleç Köksal

Key Points

  • This research evaluates pulmonary function in children following mild COVID-19 infection compared to healthy controls.
  • Prospective cross-sectional study in children aged 6–18 years with confirmed COVID-19 infection and healthy controls.
  • Assessment of pulmonary function tests (PFTs) using spirometry.
  • 2022 evaluations of post-COVID-19 patients compared to age- and sex-matched controls.
  • No significant demographic differences between post-COVID-19 group and healthy controls.
  • Higher airway resistance and lower airway reactance were noted in post-COVID-19 patients using impulse oscillometry.
  • Normal spirometric parameters observed, but some patients experienced persistent cough and dyspnea.

Abstract

Abstract Objective Although coronavirus disease 2019 (COVID‐19) usually exhibits a mild clinical course in children, concerns remain regarding persistent airway dysfunction after recovery. This study aimed to evaluate pulmonary function tests (PFTs) in children following mild COVID‐19 infection and to compare the findings with those of healthy controls. Methods In this prospective cross‐sectional study, children aged 6–18 years with polymerase chain reaction–confirmed COVID‐19 infection were identified retrospectively from February 2022 and evaluated prospectively between June and December 2022. Fifty‐eight post‐COVID‐19 patients and 56 age‐ and sex‐matched healthy controls were included, and their demographic and clinical characteristics were recorded. PFTs were assessed using impulse oscillometry (IOS) followed by spirometry. Results There were no significant differences in demographic and anthropometric measurements between the post‐COVID‐19 group and the healthy controls. In terms of IOS measurements, zR5 and R5‐20 (reflecting airway resistance) were higher and zX5 and zX20 (reflecting airway reactance) were lower in the post‐COVID‐19 group ( p = .006, p = .002, p < .001, and p = .001, respectively). No significant differences were observed in spirometric parameters, including zFEV1, zFVC, zFEV1/FVC, and zFEF25–75. Notably, three patients exhibited persistent cough and dyspnea after COVID‐19, had FEV1 values <90% predicted, positive bronchodilator reversibility, and inhalant allergen sensitization despite having no prior history of asthma or allergic rhinitis. Conclusion Children recovering from mild COVID‐19 infection may exhibit persistent airway dysfunction detectable by IOS despite normal spirometric findings. IOS appears to be a sensitive tool for identifying subclinical airway involvement in children following COVID‐19.

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Cite This Study

Beşe et al. (2026) studied this question.

synapsesocial.com/papers/69fbe382164b5133a91a2ae5https://doi.org/10.1111/pai.70347
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