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May 7, 2026Journal of Paediatrics and Child Health0 citations

Effective Use of Subcutaneous Tocilizumab in a Case of Castleman Disease Progressing From Unicentric to Multicentric Form

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SNSamuele NaviglioIRCCS Materno Infantile Burlo GarofoloFNFrancesca NicolardiUniversity of TriesteRBRossana BussaniHeart Failure & Transplant

Key Points

  • Assess the impact of subcutaneous tocilizumab therapy on patients with Castleman Disease.
  • Described a case of Castleman Disease progression from unicentric to multicentric form in a child.
  • Administered subcutaneous tocilizumab as a therapeutic intervention.
  • Monitored patient outcomes regarding quality of life and hospital admissions.
  • Subcutaneous tocilizumab therapy improved the patient's quality of life.
  • Reduced the frequency of hospital admissions previously required for intravenous infusions.

Abstract

New Findings Castleman Disease can progress from a unicentric to a multicentric form in children. Subcutaneous tocilizumab is a safe and effective therapy for patients with Castleman Disease, improving quality of life and eliminating the need for frequent hospital admissions for intravenous infusions.

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Cite This Study

Naviglio et al. (2026) studied this question.

synapsesocial.com/papers/69fbef68164b5133a91a3555https://doi.org/10.1111/jpc.70404
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unicentric Castleman disease: A case report of an atypical presentation and successful management2024 · 9 citations
  2. 2Overview of Castleman disease2020 · 473 citations
  3. 3Review of siltuximab in the treatment of multicentric Castleman’s disease2016 · 54 citations
  4. 4Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases2019 · 73 citations
  5. 5The full spectrum of Castleman disease: 273 patients studied over 20 years2017 · 208 citations