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May 7, 2026Journal of Agricultural and Food Chemistry1 citations

Design, Synthesis, Activity, and Mechanism of Novel Spirocyclic Butenolide Derivatives Containing Thiazolylhydrazone as Potential Fungicides

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TZTingting ZhangXAXinkun AnHXHe Xie

Key Points

  • The aim is to evaluate new spirocyclic butenolide derivatives containing thiazolylhydrazone for antifungal activity.
  • Design and synthesis of novel compounds
  • Assessment of antifungal activity
  • Transcriptome analysis for pathway enrichment
  • Certain derivatives exhibited concentration-dependent antifungal activity
  • Transcriptome analysis highlighted key pathways related to plasma membranes and carbohydrate metabolism
  • Findings support development of new antifungal agents

Abstract

in a concentration-dependent manner. Transcriptome analysis indicated that the pathways related to the plasma membrane, the integral component of the membrane, and carbohydrate metabolism were significantly enriched. These results could provide solid evidence for the discovery of novel antifungal agents.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a4337https://doi.org/10.1021/acs.jafc.5c15013
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